Protivovirusnыy preparat. Spetsificheski podavlyayet in vitro virusы grippa A i V (Influenza virus A, V), vklyuchaya vыsokopatogennыye podtipы A(H1N1)pdm09 i A(H5N1), a takje drugiye virusы - vozbuditeli ORVI (koronavirus (Coronavirus), assotsiirovannыy s tyajelыm ostrыm respiratornыm sindromom (TORS), rinovirus (Rhinovirus), adenovirus (Adenovirus), respiratorno-sintsitialnыy virus (Pneumovirus) i virus paragrippa (Paramyxovirus)). Po mexanizmu protivovirusnogo deystviya otnositsya k ingibitoram sliyaniya (fuzii), vzaimodeystvuyet s gemagglyutininom virusa i prepyatstvuyet sliyaniyu lipidnoy obolochki virusa i kletochnыx membran. Okazыvayet umerennoye immunomoduliruyuщyee deystviye, povыshayet ustoychivost organizma k virusnыm infektsiyam. Obladayet interferon-indutsiruyuщyey aktivnostyu - v issledovanii na mыshax induktsiya interferonov otmechalas uje cherez 16 ch, a vыsokiye titrы interferonov soxranyalis v krovi do 48 ch posle vvedeniya. Stimuliruyet kletochnыye i gumoralnыye reaktsii immuniteta: povыshayet chislo limfotsitov v krovi, v osobennosti T-kletok (CD3), povыshayet chislo T-xelperov (CD4), ne vliyaya na uroven T-supressorov (CD8), normalizuyet immunoregulyatornыy indeks, stimuliruyet fagotsitarnuyu funktsiyu makrofagov i povыshayet chislo yestestvennыx killerov (NK-kletok).

Terapevticheskaya effektivnost pri virusnыx infektsiyax proyavlyayetsya v umenshenii prodoljitelnosti i tyajesti techeniya bolezni i yee osnovnыx simptomov, a takje v snijenii chastotы razvitiya oslojneniy, svyazannыx s virusnoy infektsiyey, i obostreniy xronicheskix bakterialnыx zabolevaniy.

Otnositsya k malotoksichnыm preparatam (LD₅₀ >4 g/kg). Ne okazыvayet kakogo-libo otritsatelnogo vozdeystviya na organizm cheloveka pri peroralnom primenenii v rekomenduyemыx dozax.

Vsasыvaniye i raspredeleniye

Bыstro absorbiruyetsya iz JKT. S_max v plazme krovi dostigayetsya cherez 1.5 ch.

Umifenovir bыstro raspredelyayetsya po organam i tkanyam organizma.

Metabolizm i vыvedeniye

Metaboliziruyetsya v pecheni. T_1/2 sostavlyayet 17-21 ch.

Okolo 40% vыvoditsya v neizmenennom vide, v osnovnom s jelchyu (38.9%) i v neznachitelnom kolichestve - pochkami (0.12%). V techeniye pervыx sutok vыvoditsya 90% prinyatoy dozы.

• profilaktika i lecheniye u vzroslыx i detey: gripp A i V, drugiye ORVI;
• kompleksnaya terapiya ostrыx kishechnыx infektsiy rotavirusnoy etiologii u detey starshe 6 let;
• kompleksnaya terapiya xronicheskogo bronxita, pnevmonii i retsidiviruyuщyey gerpeticheskoy infektsii;
• profilaktika posleoperatsionnыx infektsionnыx oslojneniy.

Preparat prinimayut vnutr, do priyema piщi.

Razovaya doza: detyam v vozraste ot 6 do 12 let - 100 mg (1 kapsula), dlya vzroslыx i detey starshe 12 let - 200 mg (2 kaps. po 100 mg)

Dlya nespetsificheskoy profilaktiki i lecheniya grippa i drugix ORVI u detey i vzroslыx

Nespetsificheskaya profilaktika

V period epidemii grippa i drugix ORVI: detyam ot 6 do 12 let - 100 mg, detyam starshe 12 let i vzroslыm - 200 mg 2 raza v nedelyu v techeniye 3 nedel.

Pri neposredstvennom kontakte s bolnыmi grippom i drugimi ORVI - detyam 6 do 12 let - 100 mg, detyam starshe 12 let i vzroslыm - 200 mg 1 raz/sut v techeniye 10-14 dney.

Lecheniye grippa i drugix ORVI

Detyam ot 6 do 12 let - 100 mg, detyam starshe 12 let i vzroslыm - 200 mg 4 raza/sut (kajdыye 6 ch) v techeniye 5 sutok.

Kompleksnaya terapiya ostrыx kishechnыx infektsiy rotavirusnoy etiologii u detey starshe 6 let

Detyam ot 6 do 12 let - 100 mg, detyam starshe 12 let - 200 mg 4 raza/sut (kajdыye 6 ch) v techeniye 5 sutok.

V kompleksnoy terapii xronicheskogo bronxita, pnevmonii i retsidiviruyuщyey gerpeticheskoy infektsii

Detyam ot 6 do 12 let - 100 mg, detyam starshe 12 let i vzroslыm - 200 mg 4 raza/sut (kajdыye 6 ch) v techeniye 5-7 sutok, zatem razovuyu dozu 2 raza v nedelyu v techeniye 4 nedel.

Profilaktika posleoperatsionnыx oslojneniy

Detyam ot 6 do 12 let - 100 mg, detyam starshe 12 let i vzroslыm - 200 mg za 2 sutok do operatsii, zatem na 2 i 5 sutki posle operatsii.

Redko: allergicheskiye reaktsii.

Yesli ukazannыye pobochnыye effektы usugublyayutsya, ili poyavilis lyubыye drugiye pobochnыye effektы, patsiyent doljen soobщit ob etom vrachu.

• povыshennaya chuvstvitelnost k umifenoviru ili lyubomu komponentu preparata;
• detskiy vozrast do 6 let;
• I trimestr beremennosti.

Neobxodimo soblyudat rekomendovannuyu sxemu i dlitelnost priyema preparata. V sluchaye propuska priyema odnoy dozы preparata propuщyennuyu dozu sleduyet prinyat kak mojno ranshe i prodoljit kurs priyema preparata po nachatoy sxeme.

Vliyaniye na sposobnost k upravleniyu transportnыmi sredstvami i mexanizmami

Ne proyavlyayet tsentralnoy neyrotropnoy aktivnosti i mojet primenyatsya v meditsinskoy praktike u lits razlichnыx professiy, trebuyuщix povыshennogo vnimaniya i bыstrotы psixomotornыx reaktsiy (v t.ch. voditeli transporta, operatorы).

V issledovaniyax na jivotnыx ne bыlo vыyavleno vrednыx vozdeystviy na techeniye beremennosti, razvitiye embriona i ploda, rodovuyu deyatelnost i postnatalnoye razvitiye.

Primeneniye preparata Arbidol^® v I trimestre beremennosti protivopokazano.

Vo II i III trimestrax beremennosti Arbidol^® mojno primenyat tolko dlya lecheniya i profilaktiki grippa i v tom sluchaye, yesli predpolagayemaya polza dlya materi prevыshayet potentsialnыy risk dlya ploda. Sootnosheniye polza/risk opredelyayetsya lechaщim vrachom.

Neizvestno, vыdelyayetsya li Arbidol^® s grudnыm molokom u jenщin v period laktatsii. Pri neobxodimosti primeneniya preparata Arbidol^® sleduyet prekratit grudnoye vskarmlivaniye.

Preparat sleduyet xranit v nedostupnom dlya detey meste pri temperature ne vыshe 25°C.

Preparat otpuskayetsya bez retsepta.