Albendazol-Alium (Albendazole-Alium)retsept bilan

Ta'sir etuvchi modda(XPN):

Aktivnoye veщyestvo: albendazol (albendazole) Rec.INN zaregistrirovannoye VOZ

Preparatning savdo nomi:

Albendazol-Alium (Albendazole-Alium)

Farmakalogik guruhi:

Kliniko-farmakologicheskaya gruppa: Protivogelmintnыy preparat

1 sht. - upakovki yacheykovыye konturnыye - pachki kartonnыye.
1 sht. - upakovki yacheykovыye konturnыye (2) - pachki kartonnыye.
1 sht. - upakovki yacheykovыye konturnыye (3) - pachki kartonnыye.
1 sht. - upakovki yacheykovыye konturnыye (4) - pachki kartonnыye.
2 sht. - upakovki yacheykovыye konturnыye - pachki kartonnыye.
2 sht. - upakovki yacheykovыye konturnыye (2) - pachki kartonnыye.
2 sht. - upakovki yacheykovыye konturnыye (3) - pachki kartonnыye.
2 sht. - upakovki yacheykovыye konturnыye (4) - pachki kartonnыye.
4 sht. - upakovki yacheykovыye konturnыye - pachki kartonnыye.
4 sht. - upakovki yacheykovыye konturnыye (2) - pachki kartonnыye.
4 sht. - upakovki yacheykovыye konturnыye (3) - pachki kartonnыye.
4 sht. - upakovki yacheykovыye konturnыye (4) - pachki kartonnыye.
5 sht. - upakovki yacheykovыye konturnыye - pachki kartonnыye.
5 sht. - upakovki yacheykovыye konturnыye (2) - pachki kartonnыye.
5 sht. - upakovki yacheykovыye konturnыye (3) - pachki kartonnыye.
5 sht. - upakovki yacheykovыye konturnыye (4) - pachki kartonnыye.
10 sht. - upakovki yacheykovыye konturnыye - pachki kartonnыye.
10 sht. - upakovki yacheykovыye konturnыye (2) - pachki kartonnыye.
10 sht. - upakovki yacheykovыye konturnыye (3) - pachki kartonnыye.
10 sht. - upakovki yacheykovыye konturnыye (4) - pachki kartonnыye.

Antigelmintnoye i protivoprotozoynoye sredstvo

P02CA03

Protivogelmintnoye sredstvo shirokogo spektra deystviya; proizvodnoye benzimidazola karbamata. Protivogelmintnoye i protivoprotozoynoye sredstvo. Izbiratelno podavlyayet polimerizatsiyu beta-tubulina, chto privodit k destruktsii tsitoplazmaticheskix mikrokanaltsev kletok kishechnogo trakta gelmintov; vыzыvayet neobratimoye narusheniye utilizatsii glyukozы v organizme gelminta i tormozit sintez ATF; blokiruyet peredvijeniye sekretornыx granul i drugix organell v mыshechnыx kletkax kruglыx chervey, obuslovlivaya ix gibel. Naiboleye effektiven v otnoshenii lichinochnыx form tsestod - Echinococcus granulosus i Taenia solium; nematod - Strongyloides stercolatis.

Pri priyeme vnutr albendazol ploxo absorbiruyetsya iz JKT, v neizmenennom vide ne opredelyayetsya v plazme, biodostupnost nizkaya. Priyem jirnoy piщi povыshayet vsasыvaniye i Cmax v 5 raz. Vremya dostijeniya Cmax albendazola sulfoksida sostavlyayet 2-5 ch. Svyazыvaniye s belkami plazmы – 70%, pronikayet v znachimыx kolichestvax v jelch, pechen, spinnomozgovuyu jidkost, mochu, stenku i jidkosti tsist gelmintov. Metaboliziruyetsya v pecheni s obrazovaniyem pervichnogo metabolita (albendazola sulfoksid), obladayuщyego antigelmintnoy aktivnostyu. Albendazola sulfoksid metaboliziruyetsya v albendazola sulfon (vtorichnыy metabolit) i drugiye okislennыye produktы.

T1/2 albendazola sulfoksida - 8-12 ch. Vыvoditsya s jelchyu cherez kishechnik v vide aktivnogo metabolita albendazola sulfoksida, lish nebolshoye yego kolichestvo vыvoditsya s mochoy. Pri porajenii pecheni biodostupnost povыshayetsya, pri etom Cmax albendazola sulfoksida uvelichivayetsya v 2 raza, a T1/2 udlinyayetsya. Yavlyayetsya induktorom izofermentov CYP1A v kletkax pecheni cheloveka.

Exinokokkoz, neyrotsistitserkoz, nematodozы (askaridoz, trixotsefalez, ankilostomidoz, enterobioz, strongiloidoz), trematodozы (opistorxoz), lyamblioz, mikrosporidioz, smeshannыye gelmintozы. V kachestve vspomogatelnogo sredstva pri xirurgicheskom lechenii exinokokkoznыx kist.

Sposob primeneniya i rejim dozirovaniya konkretnogo preparata zavisyat ot yego formы vыpuska i drugix faktorov. Optimalnыy rejim dozirovaniya opredelyayet vrach. Sleduyet strogo soblyudat sootvetstviye ispolzuyemoy lekarstvennoy formы konkretnogo preparata pokazaniyam k primeneniyu i rejimu dozirovaniya.

So storonы piщyevaritelnoy sistemы: abdominalnaya bol, toshnota, rvota, povыsheniye aktivnosti pechenochnыx transaminaz.

So storonы TsNS: golovnaya bol, golovokrujeniye, meningealnыye simptomы.

So storonы sistemы krovetvoreniya: leykopeniya, granulotsitopeniya, agranulotsitoz, trombotsitopeniya, pantsitopeniya.

Allergicheskiye reaktsii: kojnaya sыp, zud.

So storonы mochevыdelitelnoy sistemы: narusheniye funktsii pochek, ostraya pochechnaya nedostatochnost.

Prochiye: gipertermiya, povыsheniye AD, alopetsiya.

Patologiya setchatki glaza, beremennost, laktatsiya (grudnoye vskarmlivaniye), detskiy vozrast do 1 goda (dlya vsex lekarstvennыx form), povыshennaya chuvstvitelnost k albendazolu.

Pri odnovremennom primenenii s deksametazonom, prazikvantelom vozmojno povыsheniye kontsentratsii albendazola sulfoksida v plazme krovi.

Obnarujeno povыsheniye kontsentratsii albendazola sulfoksida v jelchi i v soderjimom exinokokkovoy kistы pri odnovremennom primenenii albendazola i tsimetidina, chto mojet povыshat effektivnost lecheniya exinokokkoza.

S ostorojnostyu primenyayut albendazol u patsiyentov s ugneteniyem kostnomozgovogo krovetvoreniya, pechenochnoy nedostatochnostyu, tsirrozom pecheni, patologiyey setchatki glaza.

Neobxodimo prekraщyeniye terapii pri razvitii leykopenii. Pri neyrotsistitserkoze s porajeniyem glaz pered nachalom lecheniya neobxodimo issledovaniye setchatki glaza (uvelichivayetsya risk usugubleniya patologii setchatki glaza). Patsiyentы, poluchayuщiye vыsokiye dozы, doljnы naxoditsya pod tщatelnыm nablyudeniyem, pri postoyannom kontrole sostoyaniya krovi i funktsiy pecheni.

U detey sleduyet izbegat primeneniya albendazola v vыsokix dozax v techeniye dlitelnogo vremeni.

Albendazol protivopokazan k primeneniyu pri beremennosti i v period laktatsii (grudnogo vskarmlivaniya).

Jenщinam detorodnogo vozrasta v period lecheniya rekomenduyetsya ispolzovat negormonalnыye metodы kontratseptsii. Neizvestno, vыdelyayetsya li albendazol i yego aktivnыy metabolit s grudnыm molokom.

V eksperimentalnыx issledovaniyax na jivotnыx pokazana teratogennost albendazola.

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