Aktivnoye veщyestvo: tokoferol (tocopherol) Ph.Eur. Yevropeyskaya Farmakopeya
Alfa-Tokoferola atsetata rastvor v masle (vitamin Ye) (Alfa-Tocopherol acetate solution in oil (vitamin E))
Kliniko-farmakologicheskaya gruppa: Vitaminnыy preparat
Vitamin E. Okazыvayet antioksidantnoye deystviye, uchastvuyet v biosinteze gema i belkov, proliferatsii kletok, tkanevom dыxanii, drugix vajneyshix protsessax tkanevogo metabolizma, preduprejdayet gemoliz eritrotsitov, prepyatstvuyet povыshennoy pronitsayemosti i lomkosti kapillyarov; stimuliruyet sintez belkov i kollagena.
Pri priyeme vnutr absorbtsiya sostavlyayet 50-80%; v protsesse vsasыvaniya obrazuyet kompleks s lipoproteidami (vnutrikletochnыye perenoschiki tokoferola). Dlya absorbtsii neobxodimo nalichiye jelchnыx kislot. Svyazыvayetsya s alfa1- i beta-lipoproteidami, chastichno - s sыvorotochnыm albuminom. Pri narushenii obmena belkov transport zatrudnyayetsya. Cmax dostigayetsya cherez 4 ch. Metaboliziruyetsya v pecheni do proizvodnыx, imeyuщix xinonovuyu strukturu (nekotorыye iz nix obladayut vitaminnoy aktivnostyu). Vыdelyayetsya s grudnыm molokom. U nedonoshennыx i novorojdennыx detey vozmojna yego kumulyatsiya. Deponiruyetsya v nadpochechnikax, gipofize, semennikax, jirovoy i mыshechnoy tkani, eritrotsitax, pecheni. Boleye 90% vыvoditsya s jelchyu, 6% - pochkami.
Allergicheskiye reaktsii: vozmojnы zud, giperemiya koji
So storonы piщyevaritelnoy sistemы: vozmojnы diareya, toshnota, gastralgiya, dispepsiya.
Povыshennaya chuvstvitelnost k tokoferolu; tyajelыy ateroskleroz koronarnыx arteriy, infarkt miokarda, povыshennыy risk razvitiya tromboembolii; detskiy vozrast - v zavisimosti ot primenyayemoy lekarstvennoy formы.
S ostorojnostyu
Gipoprotrombinemiya (na fone defitsita vitamina K - mojet usilivatsya pri doze vitamina Ye boleye 400 ME).
Pri odnovremennom primenenii vitamin Ye usilivayet effekt GKS, NPVS, serdechnыx glikozidov.
Odnovremennoye primeneniye vitamina Ye v doze boleye 400 mg/sut s antikoagulyantami (proizvodnыmi kumarina i indandiona) povыshayet risk razvitiya gipoprotrombinemii i krovotecheniy.
Pri odnovremennom primenenii kolestiramin, kolestipol, mineralnыye masla snijayut vsasыvaniye alfa-tokoferola atsetata.
Pri odnovremennom primenenii vitamina Ye s tsiklosporinom povыshayetsya absorbtsiya poslednego.
Naznacheniye vitamina Ye v vыsokix dozax mojet vыzvat defitsit vitamina A v organizme.
Pri dlitelnom primenenii tokoferola i/ili neobxodimosti naznacheniya povtornыx kursov terapii rekomenduyetsya periodicheski kontrolirovat pokazateli svertыvaniya krovi, a takje uroven xolesterina v krovi.
Pri odnovremennom priyeme s drugimi vitaminno-mineralnыmi preparatami, soderjaщimi jirorastvorimыye vitaminы A, D i Ye, sleduyet prokonsultirovatsya s vrachom.
Stres-off
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