Alfa-Tokoferola atsetat (Alfa-Tocopherol acetate)

Ta'sir etuvchi modda(XPN):

Aktivnoye veщyestvo: tokoferol (tocopherol) Ph.Eur. Yevropeyskaya Farmakopeya

Preparatning savdo nomi:

Alfa-Tokoferola atsetat (Alfa-Tocopherol acetate)

Farmakalogik guruhi:

Kliniko-farmakologicheskaya gruppa: Vitaminnыy preparat

25 ml - flakon-kapelnitsы (1) - pachki kartonnыye.
50 ml - flakonы (1) - pachki kartonnыye.

Vitamin

A11HA03

Vitamin E. Okazыvayet antioksidantnoye deystviye, uchastvuyet v biosinteze gema i belkov, proliferatsii kletok, tkanevom dыxanii, drugix vajneyshix protsessax tkanevogo metabolizma, preduprejdayet gemoliz eritrotsitov, prepyatstvuyet povыshennoy pronitsayemosti i lomkosti kapillyarov; stimuliruyet sintez belkov i kollagena.

Pri priyeme vnutr absorbtsiya sostavlyayet 50-80%; v protsesse vsasыvaniya obrazuyet kompleks s lipoproteidami (vnutrikletochnыye perenoschiki tokoferola). Dlya absorbtsii neobxodimo nalichiye jelchnыx kislot. Svyazыvayetsya s alfa1- i beta-lipoproteidami, chastichno - s sыvorotochnыm albuminom. Pri narushenii obmena belkov transport zatrudnyayetsya. Cmax dostigayetsya cherez 4 ch. Metaboliziruyetsya v pecheni do proizvodnыx, imeyuщix xinonovuyu strukturu (nekotorыye iz nix obladayut vitaminnoy aktivnostyu). Vыdelyayetsya s grudnыm molokom. U nedonoshennыx i novorojdennыx detey vozmojna yego kumulyatsiya. Deponiruyetsya v nadpochechnikax, gipofize, semennikax, jirovoy i mыshechnoy tkani, eritrotsitax, pecheni. Boleye 90% vыvoditsya s jelchyu, 6% - pochkami.

Lecheniye i profilaktika gipovitaminoza. Sostoyaniya rekonvalestsentsii posle zabolevaniy, protekavshix s lixoradochnыm sindromom, vыsokiye fizicheskiye nagruzki, pojiloy vozrast, zabolevaniya svyazochnogo apparata i mыshts. Klimaktericheskiye vegetativnыye narusheniya. Nevrasteniya pri pereutomlenii, astenicheskiy nevrastenicheskiy sindrom, pervichnaya mыshechnaya distrofiya, posttravmaticheskaya, postinfektsionnaya vtorichnaya miopatiya. Degenerativnыye i proliferativnыye izmeneniya sustavov i svyazochnogo apparata pozvonochnika i krupnыx sustavov.

Sposob primeneniya i rejim dozirovaniya konkretnogo preparata zavisyat ot yego formы vыpuska i drugix faktorov. Optimalnыy rejim dozirovaniya opredelyayet vrach. Sleduyet strogo soblyudat sootvetstviye ispolzuyemoy lekarstvennoy formы konkretnogo preparata pokazaniyam k primeneniyu i rejimu dozirovaniya.

Allergicheskiye reaktsii: vozmojnы zud, giperemiya koji

So storonы piщyevaritelnoy sistemы: vozmojnы diareya, toshnota, gastralgiya, dispepsiya.

Povыshennaya chuvstvitelnost k tokoferolu; tyajelыy ateroskleroz koronarnыx arteriy, infarkt miokarda, povыshennыy risk razvitiya tromboembolii; detskiy vozrast - v zavisimosti ot primenyayemoy lekarstvennoy formы.

S ostorojnostyu

Gipoprotrombinemiya (na fone defitsita vitamina K - mojet usilivatsya pri doze vitamina Ye boleye 400 ME).

Pri odnovremennom primenenii vitamin Ye usilivayet effekt GKS, NPVS, serdechnыx glikozidov.

Odnovremennoye primeneniye vitamina Ye v doze boleye 400 mg/sut s antikoagulyantami (proizvodnыmi kumarina i indandiona) povыshayet risk razvitiya gipoprotrombinemii i krovotecheniy.

Pri odnovremennom primenenii kolestiramin, kolestipol, mineralnыye masla snijayut vsasыvaniye alfa-tokoferola atsetata.

Pri odnovremennom primenenii vitamina Ye s tsiklosporinom povыshayetsya absorbtsiya poslednego.

Naznacheniye vitamina Ye v vыsokix dozax mojet vыzvat defitsit vitamina A v organizme.

Pri dlitelnom primenenii tokoferola i/ili neobxodimosti naznacheniya povtornыx kursov terapii rekomenduyetsya periodicheski kontrolirovat pokazateli svertыvaniya krovi, a takje uroven xolesterina v krovi.

Pri odnovremennom priyeme s drugimi vitaminno-mineralnыmi preparatami, soderjaщimi jirorastvorimыye vitaminы A, D i Ye, sleduyet prokonsultirovatsya s vrachom.

Primeneniye tokoferola pri beremennosti i v period laktatsii (grudnogo vskarmlivaniya) vozmojno tolko po naznacheniyu vracha.

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