Aevit (Aevit)

Ta'sir etuvchi modda(XPN):

Aktivnыye veщyestva tokoferol (tocopherol) Ph.Eur. Yevropeyskaya Farmakopeya retinol (retinol) Rec.INN zaregistrirovannoye VOZ

Preparatning savdo nomi:

Aevit (Aevit)

Farmakalogik guruhi:

Kliniko-farmakologicheskiye gruppы

  • Kompleks vitaminov
  • Preparat, uluchshayuщiy trofiku i regeneratsiyu tkaney, dlya narujnogo primeneniya

10 sht. - blisterы (1) - pachki kartonnыye.
10 sht. - blisterы (2) - pachki kartonnыye.

Polivitamin

A11JA

Kombinirovannoye lekarstvennoye sredstvo, deystviye kotorogo opredelyayetsya svoystvami vxodyaщix v yego sostav jirorastvorimыx vitaminov A i Ye.

Retinol (vitamin A): yavlyayetsya neobxodimыm komponentom dlya normalnoy funktsii setchatoy obolochki glaza: svyazыvayas s opsinom (krasnыm pigmentom setchatoy obolochki), obrazuyet zritelnыy purpur rodopsin, neobxodimыy dlya zritelnoy adaptatsii v temnote. Vitamin A neobxodim dlya rosta kostey, normalnoy reproduktivnoy funktsii, embrionalnogo razvitiya, dlya regulyatsii deleniya i differentsirovki epiteliya (usilivayet razmnojeniye epitelialnыx kletok koji, omolajivayet kletochnuyu populyatsiyu, tormozit protsessы keratinizatsii). Vitamin A prinimayet uchastiye v kachestve kofaktora v razlichnыx bioximicheskix protsessax.

Funktsiya α-tokoferola (vitamina Ye): kak antioksidant, tormozit razvitiye svobodnoradikalnыx reaktsiy, preduprejdayet obrazovaniye perekisey, povrejdayuщix kletochnыye i subkletochnыye membranы, chto imeyet vajnoye znacheniye dlya razvitiya organizma, normalnoy funktsii nervnoy i mыshechnoy sistem. Sovmestno s selenom tormozit okisleniye nenasыщyennыx jirnыx kislot (komponent mikrosomalnoy sistemы perenosa elektronov), preduprejdayet gemoliz eritrotsitov. Yavlyayetsya kofaktorom nekotorыx fermentnыx sistem. Vosstanavlivayet kapillyarnoye krovoobraщyeniye, normalizuyet kapillyarnuyu i tkanevuyu pronitsayemost, povыshayet ustoychivost tkaney k gipoksii.

Tokoferol: pri priyeme vnutr medlenno vsasыvayetsya primerno 50% prinyatoy dozы preparata, Cmax cherez 4 ch. Dlya absorbtsii neobxodimo nalichiye jelchnыx kislot. Deponiruyetsya v nadpochechnikax, gipofize, semennikax, jirovoy i mыshechnoy tkani, eritrotsitax, pecheni. Podvergayetsya metabolizmu i vыdelyayetsya iz organizma (v neizmennom vide i v vide metabolitov) s jelchyu (svыshe 90%) i mochoy (okolo 6%).

Retinol: pri priyeme vnutr retinol vsasыvayetsya pochti polnostyu, daje pri izbыtochnom vvedenii yego vыdelyayetsya s kalom ne boleye 10% ot vvedennogo kolichestva. V protsesse metabolizma obrazuyutsya retinilpalmitat, retinol, retinal i retinoyevaya kislota. Raspredelyayetsya v organizme neravnomerno: naibolsheye kolichestvo naxoditsya v pecheni i setchatke, mensheye – v pochkax, serdtse, jirovыx depo, legkix, laktiruyuщyey molochnoy jeleze, v nadpochechnikax i drugix jelezax vnutrenney sekretsii. Retinol, retinal, retinoyevaya kislota vыdelyayutsya gepatotsitami v sostave jelchi, retinoilglyukuronid vыdelyayetsya s mochoy.

Eliminirovaniye jirorastvorimыx vitaminov (tokoferola i retinola) osuщyestvlyayetsya medlenno, poetomu povtornыye priyemы privodyat k kumulyatsii.

Gipo- i avitaminoz A i Ye, a takje sostoyaniya povыshennoy potrebnosti organizma v vitaminax A i Ye i/ili snijeniye ix postupleniya v organizm: gastrektomiya, diareya, steatoreya, tseliakiya, bolezn Krona, sindrom malabsorbtsii, xronicheskiy xolestaz, tsirroz pecheni, atreziya jelchnыx putey, obstruktivnaya jeltuxa, kistoznыy fibroz podjeludochnoy jelezы, tropicheskaya spru, infektsionnыye zabolevaniya (v t.ch. xronicheskiye i "prostudnыye"), gemeralopiya, kseroftalmiya, keratomalyatsiya, nepolnotsennoye i nesbalansirovannoye pitaniye (v t.ch. parenteralnoye pitaniye), bыstroye poxudaniye, nikotinovaya zavisimost, narkomaniya, sostoyaniye dlitelnogo stressa, priyem kolestiramina, kolestipola, mineralnыx masel, neomitsina, jelezosoderjaщix produktov, pri naznachenii diyetы s povыshennыm soderjaniyem polinenasыщyennыx jirnыx kislot, gipertireoz.

Perifericheskaya nevropatiya, nekrotiziruyuщaya miopatiya, abetalipoproteinemiya.

Sposob primeneniya i rejim dozirovaniya konkretnogo preparata zavisyat ot yego formы vыpuska i drugix faktorov. Optimalnыy rejim dozirovaniya opredelyayet vrach. Sleduyet strogo soblyudat sootvetstviye ispolzuyemoy lekarstvennoy formы konkretnogo preparata pokazaniyam k primeneniyu i rejimu dozirovaniya.

Sistemnыye reaktsii: allergicheskiye reaktsii.

So storonы piщyevaritelnoy sistemы: bol v epigastralnoy oblasti, dispepsicheskiye rasstroystva (toshnota, rvota, diareya); pri dlitelnom primenenii v bolshix dozax vozmojno obostreniye xolelitiaza i xronicheskogo pankreatita.

Mestnыye reaktsii (pri v/m vvedenii) - boleznennost, infiltrat, kaltsifikatsiya myagkix tkaney.

Giperchuvstvitelnost, gipervitaminoz A i Ye, detskiy vozrast (do 18 let), beremennost, period laktatsii.

S ostorojnostyu

Tireotoksikoz, xoletsistit, sostoyaniya, soprovojdayuщiyesya povыshennoy pronitsayemostyu sosudov (XSN, xronicheskiy glomerulonefrit i dr.), tsirroz pecheni, virusnыy gepatit, pochechnaya nedostatochnost, alkogolizm, pojiloy vozrast, gipoprotrombinemiya (na fone defitsita vitamina K - mojet usilivatsya pri doze vitamina Ye boleye 400 MЕ).

Retinol oslablyayet effekt preparatov kaltsiya, uvelichivayet risk razvitiya giperkaltsiyemii.

Kolestiramin, kolestipol, mineralnыye masla, neomitsin umenshayut absorbtsiyu vitaminov A i Ye (mojet potrebovatsya povыsheniye ix dozы).

Peroralnыye kontratseptivы uvelichivayut kontsentratsiyu retinola v plazme.

Izotretinoin uvelichivayet risk razvitiya intoksikatsii retinola.

Odnovremennoye primeneniye tetratsiklina i retinola v vыsokix dozax (50 tыs.YED i vыshe) uvelichivayut risk razvitiya vnutricherepnoy gipertenzii.

Tokoferol (vitamin Ye) usilivayet effekt GKS, NPVP, antioksidantov, uvelichivayet effektivnost i umenshayet toksichnost vitaminov A, D, serdechnыx glikozidov. Naznacheniye vitamina Ye v vыsokix dozax mojet vыzvat defitsit vitamina A v organizme.

Tokoferol (vitamin Ye) povыshayet effektivnost protivoepilepticheskix LS u bolnыx epilepsiyey (u kotorыx povыsheno soderjaniye v krovi produktov perekisnogo okisleniya lipidov).

Odnovremennoye primeneniye vitamina Ye v doze boleye 400 YED/sut s antikoagulyantami (proizvodnыmi kumarina i indandiona) povыshayet risk razvitiya gipoprotrombinemii i krovotecheniy.

Primeneniye preparatov jeleza v vыsokix dozax usilivayet okislitelnыye protsessы v organizme, chto povыshayet potrebnost v vitamine Ye.

Vo izbejaniye razvitiya gipervitaminoza A i Ye ne sleduyet prevыshat rekomenduyemыx doz.

Pri primenenii preparata sleduyet uchitыvat bolshoye soderjaniye v nem vitamina A (100 tыs.MЕ), a takje chto on yavlyayetsya lechebnыm, a ne profilakticheskim LS.

Diyeta s povыshennыm soderjaniyem Se i serosoderjaщix aminokislot snijayet potrebnost v vitamine Ye.

Protivopokazan pri beremennosti i v period laktatsii (grudnogo vskarmlivaniya).

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