5-НОК® (5-NOK®)retsept bilan

Ta'sir etuvchi modda(XPN):

Aktivnoye veщyestvo: nitroksolin (nitroxoline) Rec.INN zaregistrirovannoye VOZ

Preparatning savdo nomi:

5-NOK® (5-NOK®)

Farmakalogik guruhi:

Kliniko-farmakologicheskaya gruppa: Antibakterialnыy preparat, proizvodnoye 8-oksixinolina. Uroantiseptik

Tabletki, pokrыtыye obolochkoy oranjevogo tsveta, kruglыye, dvoyakovыpuklыye, blestyaщiye.

Protivomikrobnoye sredstvo, oksixinolin

J01XX07

Protivomikrobnoye sredstvo, proizvodnoye 8-oksixinolina. Mexanizm deystviya svyazan s selektivnыm ingibirovaniyem sinteza bakterialnoy DNK.

Nitroksolin aktiven v otnoshenii grampolojitelnыx bakteriy: Staphylococcus spp. (v t.ch. Staphylococcus aureus), Streptococcus spp. (v t.ch. β-gemoliticheskiye streptokokki, Streptococcus pneumoniae, Enterococcus faecalis), Corynebacterium diphtheriae, Bacillus subtilis; gramotritsatelnыx bakteriy: Neisseria gonorrhoeae, Escherichia coli, Proteus spp., Klebsiella spp., Salmonella spp., Shigella spp., Enterobacter spp.

Nitroksolin aktiven takje v otnoshenii Mycobacterium tuberculosis, Trichomonas vaginalis, nekotorыx vidov gribov (Candida spp., dermatofitы, pleseni, nekotorыye vozbuditeli glubokix mikozov).

Posle priyema vnutr v vыsokoy stepeni absorbiruyetsya iz JKT.

Vыvoditsya pochkami v neizmenennom vide. V moche opredelyayutsya vыsokiye kontsentratsii nitroksolina.

Infektsionno-vospalitelnыye zabolevaniya preimuщyestvenno mochepolovыx putey (v t.ch. piyelonefrit, tsistit, uretrit, epididimit, infitsirovannaya adenoma ili kartsinoma predstatelnoy jelezы), vыzvannыye chuvstvitelnыmi k nitroksolinu mikroorganizmami. Profilaktika infektsionnыx oslojneniy pri diagnosticheskix i lechebnыx manipulyatsiyax (kateterizatsiya, tsistoskopiya) v posleoperatsionnom periode pri xirurgicheskix vmeshatelstvax na pochkax i mochepolovыx putyax.

Sposob primeneniya i rejim dozirovaniya konkretnogo preparata zavisyat ot yego formы vыpuska i drugix faktorov. Optimalnыy rejim dozirovaniya opredelyayet vrach. Sleduyet strogo soblyudat sootvetstviye ispolzuyemoy lekarstvennoy formы konkretnogo preparata pokazaniyam k primeneniyu i rejimu dozirovaniya.

So storonы piщyevaritelnoy sistemы: toshnota, rvota, poterya appetita; v yedinichnыx sluchayax - narusheniya funktsii pecheni.

Allergicheskiye reaktsii: kojnaya sыp, zud.

So storonы TsNS i perifericheskoy nervnoy sistemы: v yedinichnыx sluchayax - ataksiya, golovnaya bol, parestezii, polinevropatiya; pri dlitelnom primenenii opisan sluchay razvitiya nevrita glaznogo nerva.

So storonы serdechno-sosudistoy sistemы: v yedinichnыx sluchayax - taxikardiya.

Narusheniya funktsii pochek, soprovojdayuщiyesya oligo- ili anuriyey, tyajelыye zabolevaniya pecheni, defitsit glyukozo-6-fosfatdegidrogenazы, katarakta, nevrit, beremennost, laktatsiya, povыshennaya chuvstvitelnost k preparatam xinolinovogo ryada.

Na fone primeneniya nitroksolina mocha okrashivayetsya v shafranno-jeltыy tsvet.

Nitroksolin protivopokazan k primeneniyu pri beremennosti i v period laktatsii (grudnogo vskarmlivaniya).

LEK d.d. (Sloveniya)

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